Human Cell Lines

Explore and request access to available collections of cell line models of Down syndrome, including induced pluripotent stem cells

Human induced pluripotent stem cells (iPSCs) were generated from urine-derived renal epithelial cells or white blood cells using a cocktail of mRNAs encoding six reprogramming factors (a modified version of Oct4 fused with the MyoD transactivation domain (called M3O), Sox2, Klf4, cMyc, Lin28A, and Nanog) along with the reprogramming mimic miRNAs -367 and -302 to reprogram cells. [PMID: 29467427]

All human study participants were enrolled in the Crnic Institute's Human Trisome Project (HTP) under a study protocol approved by the Colorado Multiple Institutional Review Board (COMIRB 15-2170 and NCT02864108; see also www.trisome.org). Written informed consent was obtained from all study participants or their legal guardians.

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